The glycine site of NMDA receptors:
A target for cognitive enhancement in psychiatric disorders
•
The Best Natural Option to Support
NMDA-R Function.
The glycine site of NMDA receptors:
A target for cognitive enhancement in psychiatric disorders
•
“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”
T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎
• Progress in Neuropsychopharmacology & Biological Psychiatry 92 (2019) 387–404
Glycine acts as a co-factor to safely activate the receptor.
NMDA-R is co-activated by Glutamate and Glycine.
Glutamate activity in excess can product excitotoxicity causing damage and death to neurons
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NAC Increases Glutathione - The body's vital Master Antioxidant found in virtually every human cell*.
NAC regulates
Glutamate in the
synapse between neurons
to improve NMDA-R
function and prevent excitoxicity.
NAC provides strong protection from environmental toxins.
NAC has both direct and indirect improvement of
NMDA-R function.
Sarcosine Enhances
Memory, Focus, & Executive Function*
Clinical studies were identified evaluating the effects of glycine site modulators in healthy participants as well as in participants with mood disorders (both bipolar and unipolar depression),
anxiety and related disorders
(including OCD and PTSD) and
major neurocognitive disorders
(i.e., Alzheimer's disease).
These proofs-of-concept
clinical trials revealed promising result in support of NMDAR glycine site agonists having transdiagnostic antidepressant
and pro-cognitive effects.
LONG TERM POTENTIATION (LTP)
Sarcosine is a competitive Inhibitor of the
Type 1 Glycine Transporter (GlyT1).
It safely activates the NMDA Receptor and avoids excitotoxicity issues associated with Glutamate.
Sarcosine breakdown results in Glycine, further increasing concentrations in the brain.
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The glycine site of NMDA receptors:
A target for cognitive enhancement in psychiatric disorders
•
“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”
T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎
• Progress in Neuropsychopharmacology & Biological Psychiatry 92 (2019) 387–404
I’m a paragraph. Double click
me or click Edit Text. It's easy to make it your own.
Sarcosine
is the only available
Glycine Transporter Type 1 (GlyT1) Inhibitor *
“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”
• The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders
• T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎
• Progress in Neuropsychopharmacology & Biological Psychiatry 92 (2019) 387–404
Clinical studies were identified evaluating the effects of glycine site modulators in healthy participants as well as in participants with mood disorders (both bipolar and unipolar depression),
anxiety and related disorders
(including OCD and PTSD) and
major neurocognitive disorders
(i.e., Alzheimer's disease).
These proofs-of-concept
clinical trials revealed promising result in support of NMDAR glycine site agonists having transdiagnostic antidepressant
and pro-cognitive effects.
NMDA Receptor Actions are Essential to Memory, Learning, Personality and Higher Cognitive Function
The NMDA Receptor Plays a Critical Role in
Cognitive and Psychological Function
Naturally safe:
“NAC has been in use for over 30 years as an antidote for Tylenol overdose, treatment for chronic obstructive pulmonary disease (COPD), a renal protectant for nephropathy and the management of HIV. A groundswell of recent evidence suggests benefits in multiple neuropsychiatric disorders.” (I edited this a bit-see below)
o The promise of N-acetylcysteine in neuropsychiatry
- Michael Berk1,2,3,4, Gin S. Malhi5,6, Laura J. Gray1, and Olivia M. Dean1,2,4
NAC is a precursor for Glutathione, an essential amino acid naturally found in the human body