The glycine site of NMDA receptors:

A target for cognitive enhancement in psychiatric disorders 

• 

The Best Natural Option to Support

 NMDA-R Function.

The glycine site of NMDA receptors:

A target for cognitive enhancement in psychiatric disorders 

• 

“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”

   T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎ 

                                      •    Progress in Neuropsychopharmacology & Biological Psychiatry 92   (2019) 387–404 

Glycine acts as a co-factor to safely activate the receptor.

NMDA-R is co-activated by Glutamate and Glycine. 

Glutamate activity in excess can product excitotoxicity causing damage and death to neurons

“LTP Leads to Structural and Functional Changes of the Synapse that

Make Neurotransmission More Efficient.”

Stahl’s Essential Psychopharmacology:

Neuroscientific Basis and Practical Applications. 

3rd Ed. 2008, Stephen Stahl

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NAC Increases Glutathione - The body's vital Master Antioxidant found in virtually every human cell*. 

NAC regulates

Glutamate in the

synapse between neurons

to improve NMDA-R

function and prevent excitoxicity. 

NAC provides strong protection from environmental toxins.

NAC has both direct and indirect improvement of 

NMDA-R function. 

Sarcosine Enhances 

Memory, Focus, & Executive Function*

Clinical studies were identified evaluating the effects of glycine site modulators in healthy participants as well as in participants with mood disorders (both bipolar and unipolar depression),

anxiety and related disorders

(including OCD and PTSD) and

major neurocognitive disorders

(i.e., Alzheimer's disease).

These proofs-of-concept

clinical trials revealed promising result in support of NMDAR glycine site agonists having transdiagnostic antidepressant

and pro-cognitive effects.

LONG TERM POTENTIATION (LTP)

Sarcosine is a competitive Inhibitor of the

Type 1 Glycine Transporter (GlyT1). 

It safely activates the NMDA Receptor and avoids excitotoxicity issues associated with Glutamate. 

Sarcosine breakdown results in Glycine, further increasing concentrations in the brain. 

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The glycine site of NMDA receptors:

A target for cognitive enhancement in psychiatric disorders 

• 

“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”

   T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎ 

                                      •    Progress in Neuropsychopharmacology & Biological Psychiatry 92   (2019) 387–404 

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me or click Edit Text. It's easy  to make it your own.

Sarcosine

is the only available

Glycine Transporter Type 1 (GlyT1) Inhibitor *

“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”

   •    The glycine site of NMDA receptors: A target for cognitive enhancement in psychiatric disorders

 

•    T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎ 

                                      •    Progress in Neuropsychopharmacology & Biological Psychiatry 92   (2019) 387–404 

Clinical studies were identified evaluating the effects of glycine site modulators in healthy participants as well as in participants with mood disorders (both bipolar and unipolar depression),

anxiety and related disorders

(including OCD and PTSD) and

major neurocognitive disorders

(i.e., Alzheimer's disease).

These proofs-of-concept

clinical trials revealed promising result in support of NMDAR glycine site agonists having transdiagnostic antidepressant

and pro-cognitive effects.

NMDA Receptor Actions are Essential to Memory, Learning, Personality and Higher Cognitive Function

The NMDA Receptor Plays a Critical Role in

Cognitive and Psychological Function

Naturally safe:

 

“NAC has been in use for over 30 years as an antidote for Tylenol overdose, treatment for chronic obstructive pulmonary disease (COPD), a renal protectant for nephropathy and the management of HIV. A groundswell of recent evidence suggests benefits in multiple neuropsychiatric disorders.” (I edited this a bit-see below) 

o The promise of N-acetylcysteine in neuropsychiatry

- Michael Berk1,2,3,4, Gin S. Malhi5,6, Laura J. Gray1, and Olivia M. Dean1,2,4

 

NAC is a precursor for Glutathione, an essential amino acid naturally found in the human body

*Disclaimer: The text on this website is for informational purposes only and should not be used in substitute for the advice of a physician or other medical professional. All statements and information on this website have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

 

We recommend the use of our products in coordination with a knowledgeable healthcare specialist.

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