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The glycine site of NMDA receptors:

A target for cognitive enhancement in psychiatric disorders 


The Best Natural Option to Support

 NMDA-R Function.

The glycine site of NMDA receptors:

A target for cognitive enhancement in psychiatric disorders 


“Sarcosine has had positive results in improving cognitive symptoms in numerous Randomized Controlled Trials.”

   T Bahareh Peyroviana, Joshua D. Rosenblata,b, Zihang Pana,c, Michelle Iacobuccia, Elisa Brietzkea,d, Roger S. McIntyrea,b,c,e,f,⁎ 

                                      •    Progress in Neuropsychopharmacology & Biological Psychiatry 92   (2019) 387–404 

Glycine acts as a co-factor to safely activate the receptor.

NMDA-R is co-activated by Glutamate and Glycine. 

Glutamate activity in excess can product excitotoxicity causing damage and death to neurons

“LTP Leads to Structural and Functional Changes of the Synapse that

Make Neurotransmission More Efficient.”

Stahl’s Essential Psychopharmacology:

Neuroscientific Basis and Practical Applications. 

3rd Ed. 2008, Stephen Stahl

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NAC Increases Glutathione - The body's vital Master Antioxidant found in virtually every human cell*. 

NAC regulates

Glutamate in the

synapse between neurons

to improve NMDA-R

function and prevent excitoxicity. 

NAC provides strong protection from environmental toxins.

NAC has both direct and indirect improvement of 

NMDA-R function. 

Sarcosine Enhances 

Memory, Focus, & Executive Function*

Clinical studies were identified evaluating the effects of glycine site modulators in healthy participants as well as in participants with mood disorders (both bipolar and unipolar depression),

anxiety and related disorders

(including OCD and PTSD) and

major neurocognitive disorders

(i.e., Alzheimer's disease).

These proofs-of-concept

clinical trials revealed promising result in support of NMDAR glycine site agonists having transdiagnostic antidepressant

and pro-cognitive effects.


Sarcosine is a competitive Inhibitor of the

Type 1 Glycine Transporter (GlyT1).