NMDA RECEPTOR ACTIONS ARE ESSENTIAL TO
The NMDA Receptor plays a
critical role in
cognitive and psychological functions.
The NMDA (N-Methyl D-Aspartate) Receptor
NMDA-R is co-activated by Glutamate and Glycine.
Glycine acts as a co-factor to safely activate the receptor.
Glutamate activity in excess can produce excitotoxicity causing damage and death to neurons
NMDA is a Receptor in the
Glutamate Neurotransmitter System (GNS)
NMDA-Rs have a role to play in diverse
and complex processes of mind and brain including:
Memory Formation and Long Term Potentiation (LTP)
Excitotoxicity and Stroke Outcome
Ego and Frontal Lobe Function
Pain and Opiate Tolerance
Alcoholism and Drug Abuse
Schizophrenia and Depression
Age-Related Memory Decline
Dementia and Alzheimers
“Long Term Potentiation (LTP)
Leads to Structural and Functional Changes of the Synapse that
Make Neurotransmission More Efficient.”
Stahl S. Stahl’s Essential Psychopharmacology:
Neuroscientific Basis and Practical Applications.
3rd Ed. 2008,
NMDA-R abnormalities contribute to
cognitive and psychological deficits
that are challenging to treat.